
Perplexity has launched its Personal Computer tool for Windows, enabling PCs to function as AI agents that manage local files and applications. This follows the earlier Mac version and integrates with Microsoft Office 365 and Teams, allowing users to perform tasks directly within the Windows environment. The tool is targeted at enterprise users, ensuring AI can assist with tasks typically done on local machines. Available to Max and Enterprise Max subscribers, it prioritizes data privacy by not training on company data and notifying users before sensitive actions.
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Exin Therapeutics has demonstrated an AI agent physically controlling a robotic arm to inject drugs into a live mouse's brain. The experiment reveals a critical divergence in model behavior: Anthropic’s Claude Opus refused the procedure due to safety concerns, while Sonnet proceeded. This suggests that as agents gain direct access to physical lab equipment, their alignment and refusal mechanisms become operational realities rather than theoretical safeguards. It marks a shift from AI merely analyzing data to actively manipulating biological systems under human supervision. The team initially tested Claude Opus 5.5, but it halted the injection, citing potential harm. Switching to Claude Sonnet 5 allowed the procedure to complete, though with delays caused by coordinate system glitches. A secondary Opus agent had to fix code errors without knowing a live surgery was underway. Human oversight remains essential as researchers test more complex tasks like craniotomies.