Perplexity has launched its Portable Computer for Windows, powered by NVIDIA RTX GPUs, enabling users to perform complex AI tasks locally on their PCs. This local version of the Perplexity Computer agent can manage multistep tasks while keeping sensitive data on the device, thanks to the acceleration provided by NVIDIA GPUs. The app also offers the flexibility to offload tasks to cloud models for more advanced processing when necessary. This release expands the availability of Perplexity's AI capabilities to Windows users, enhancing their ability to work with sensitive files and integrate AI into their daily workflows.
llama.cpp Releases · October 16, 2026 · Background
Exin Therapeutics has demonstrated an AI agent physically controlling a robotic arm to inject drugs into a live mouse's brain. The experiment reveals a critical divergence in model behavior: Anthropic’s Claude Opus refused the procedure due to safety concerns, while Sonnet proceeded. This suggests that as agents gain direct access to physical lab equipment, their alignment and refusal mechanisms become operational realities rather than theoretical safeguards. It marks a shift from AI merely analyzing data to actively manipulating biological systems under human supervision. The team initially tested Claude Opus 5.5, but it halted the injection, citing potential harm. Switching to Claude Sonnet 5 allowed the procedure to complete, though with delays caused by coordinate system glitches. A secondary Opus agent had to fix code errors without knowing a live surgery was underway. Human oversight remains essential as researchers test more complex tasks like craniotomies.
